Thioguanine and the enzyme TPMT
Thioguanine is processed to a large extent by the enzymes TPMT and NUDT15. The activity of these enzymes can vary considerably depending on your genetic predisposition, which means the efficacy of thioguanine can also differ from person to person.
Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with thioguanine.
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