Tamoxifen

Tamoxifen is a drug forming part of the class of drugs known as selective oestrogen receptor modulators (SERMs). Tamoxifen has an anti-oestrogen effect and inhibits the growth of oestrogen-sensitive tumours. It also reduces swelling of the mammary glands in women and men. The drug is prescribed in cases of breast cancer, severe breast pain during menstruation and reduced fertility, and is also administered to men who experience swelling of the breasts as a side effect of medication.

Tamoxifen and the benefit of DNA analysis

The rate at which tamoxifen is processed within your body varies from one individual to another. This means that the efficacy and side effects of tamoxifen can be predicted to some extent on the basis of your genes. Preventive DNA analysis can therefore be an important tool in optimising your medication.

Tamoxifen and the enzyme CYP2D6

Tamoxifen is processed to a large extent by the enzyme CYP2D6. The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of tamoxifen and the risk of side effects can differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with tamoxifen.

Read more about The enzyme CYP2D6 »