Propafenone

Propafenone is an antiarrhythmic drug forming part of the class of drugs known as class 1C antiarrhythmics (sodium channel blockers). Propafenone decreases and regulates the heart rate by slowing the conduction of impulses through the nerves and decreasing the sensitivity of the heart muscle. It is prescribed to treat cardiac arrhythmia (such as atrial fibrillation) as well as to prevent arrhythmias.

Propafenone and the benefit of DNA analysis

The rate at which propafenone is processed within your body varies from one individual to another. This means that the efficacy and side effects of propafenone can be predicted to some extent on the basis of your genes. Preventive DNA analysis can therefore be an important tool in optimising your medication.

Propafenone and the enzyme CYP2D6

Propafenone is processed to a large extent by the enzyme CYP2D6. The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of propafenone can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with propafenone.

Read more about The enzyme CYP2D6 »