Azathioprine

Azathioprine is an immunosuppressant – a drug that suppresses the function of the immune system. It forms part of the thiopurine class of drugs. Azathioprine is prescribed to prevent rejection following organ transplants, as well as to treat inflammatory diseases (such as certain bowel diseases, rheumatoid arthritis, severe dermatitis and lupus erythematosus), hepatitis, the blood-clotting disorder ITP and serious forms of anaemia.

Azathioprine and the benefit of DNA analysis

The rate at which azathioprine is processed within your body varies from one individual to another. This means that the efficacy and side effects of azathioprine can be predicted to some extent on the basis of your genes. Preventive DNA analysis can therefore be an important tool in optimising your medication.

Azathioprine and the enzyme NUDT15

Azathioprine is processed to a large extent by the enzyme NUDT15 and TPMT. The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of azathioprine can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with azathioprine.

Read more about The enzyme NUDT15 »

Azathioprine and the enzyme NUDT15 and TPMT

Azathioprine is processed to a large extent by the enzyme NUDT15 and TPMT. The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of azathioprine can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with azathioprine.

Read more about NUDT15 / TPMT and thiopurines »

Azathioprine and the enzyme TPMT

Azathioprine is processed to a large extent by the enzyme TPMT. The activity of this enzyme can vary considerably depending on your genetic predisposition, which means the efficacy of azathioprine can also differ from person to person.

Information about your genetic predisposition may therefore provide grounds for extra vigilance in relation to a treatment with azathioprine.

Read more about The enzyme TPMT »
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